High Potency Triple Retinol Renewal Serum

Perricone MD

Where to buy Possibly in stock

About this product

The Perricone MD High Potency Triple Retinol Renewal Serum is a serums, essence, ampoule. Our analysis of its 64 ingredients (51 low-risk) rates it Excellent (95/100). Based on its ingredients, it looks well-suited to oily / acne-prone and dry skin.

Vegan-friendly Reef-safe

Summarised from our ingredient analysis — not brand marketing copy.

At a glance

Type
Serums, Essence, Ampoules
Ingredients
64
Low-risk
51
Fragrance
Fragrance-free
Origin
United States

The evidence

Quick Product Notes

Paraben-Free Sulfate-Free Alcohol-Free Silicone-Free EU Allergen-Free Fungal Acne (Malassezia) Safe

Notable Effects & Ingredients

No Notable Effects & Ingredients

Ingredients Related to Skin Types

Good   Bad — tap a skin type to see which ingredients · estimated from ingredient functions
Dry Skin 18/11
Good for dry skin
Glyceryl Caprylate Mannose Cetyl Palmitate Sodium Mannose Phosphate Sodium Acetylated Hyaluronate Sodium Hyaluronate Crosspolymer Squalane Squalene Caprylic/Capric Triglyceride Butylene Glycol Sodium Hyaluronate Glycerin Hydrolyzed Glycosaminoglycans Hydrolyzed Hyaluronic Acid Hyaluronic Acid Dimethicone Lactic Acid Lecithin
Caution for dry skin
Glyceryl Caprylate Lysolecithin Sorbitan Isostearate Glycerin Hydrogenated Phosphatidylcholine Laureth-23 Sodium Hydroxide Polysorbate 20 Polysorbate 60 Lecithin Trideceth-6 Phosphate
Oily/Acne-Prone Skin 1/0
Good for oily/acne-prone skin
Retinol
Sensitive Skin 8/15
Good for sensitive skin
Ascorbyl Palmitate Ubiquinone Glycerin Thioctic Acid Dimethicone Tocopheryl Acetate Allantoin Aloe Barbadensis Leaf
Caution for sensitive skin
p-Anisic Acid Beta-Sitosterol Cetyl Palmitate Ascorbyl Palmitate Caprylic/Capric Triglyceride Butylene Glycol Glycerin Citric Acid Sodium Benzoate Potassium Sorbate Lactic Acid Phenoxyethanol Retinol Retinyl Linoleate Aloe Barbadensis Leaf

Ingredients list

64 total
Lower hazard (1) Higher hazard (9)
All64 Skin Conditioning52 Humectant13 Fragrance11 Masking9 Emulsifying9 Surfactant9 Emollient7 Hair Conditioning7
EWG CIR Ingredient Name & Cosmetic Functions Notes
1
Water
(Solvent)
2
A
Glycerin
(Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care Agent, Oral Health Care Drug, Skin Protecting, Viscosity Decreasing Agent, Perfuming, Solvent)
Good for Dry Skin
Good for Dry Skin
Fungal Acne
Fungal Acne Trigger
3
A
Dimethicone
(Antifoaming Agent, Skin Protecting, Emollient, Skin Conditioning)
Silicone
Silicone
1
Propanediol
(Solvent, Viscosity Decreasing Agent, Viscosity Controlling)
1
A
Squalane
(Emollient, Hair Conditioning, Refatting, Skin Conditioning)
1
A
Butylene Glycol
(Fragrance, Skin Conditioning, Solvent, Viscositydecreasing Agent, Humectant, Masking, Viscosity Controlling)
Good for Dry Skin
Good for Dry Skin
1
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
(Emulsion Stabilising, Viscosity Controlling)
1
A
Niacinamide
(Hair Conditioning, Skin Conditioning, Smoothing)
Rubus Idaeus Seed Oil
(Skin Conditioning Emollient)
1
Lactobacillus Ferment
(Skin Conditioning)
4
A
Phenoxyethanol
(Fragrance, Preservative)
Paraben
Paraben
1
Polyacrylate Crosspolymer-6
(Emulsion Stabilising, Viscosity Controlling)
1
A
Pentylene Glycol
(Skin Conditioning, Solvent)
1
A
Caprylic/Capric Triglyceride
(Emollient, Masking, Perfuming, Skin Conditioning, Solvent)
1
A
Ethylhexylglycerin
(Deodorant, Skin Conditioning)
Linum Usitatissimum Seed Extract
(Perfuming, Skin Conditioning)
1
Tetrasodium Glutamate Diacetate
(Chelating Agent)
1
A
Mannose
(Humectant)
1
Sodium Mannose Phosphate
(Humectant, Skin Conditioning)
1
Ceramide NP
(Hair Conditioning, Skin Conditioning)
1
A
Allantoin
(Skin Conditioning, Skin Protecting, Soothing)
Good for Oily Skin
Good for Oily Skin
Good for Sensitive Skin
Good for Sensitive Skin
B
Aloe Barbadensis Leaf
(Masking)
Good for Sensitive Skin
Good for Sensitive Skin
Bisabolol
(Fragrance, Skin Conditioning, Soothing)
9
A
Retinol
(Skin Conditioning)
Bad for Sensitive Skin
Bad for Sensitive Skin
3
B
Polysorbate 20
(Emulsifying, Surfactant)
Fungal Acne
Fungal Acne Trigger
2
3
Lecithin
(Skin Conditioning, Emulsifying, Surfactant, Antistatic Agent, Emollient)
3
B
Polysorbate 60
(Emulsifying, Surfactant)
Fungal Acne
Fungal Acne Trigger
1
A
Sorbitan Isostearate
(Emulsifying, Surfactant)
1
Chlorella Vulgaris Extract
(Skin Conditioning)
1
A
Hydrogenated Phosphatidylcholine
(Skin Conditioning, Emulsifying, Surfactant)
1
A
Lysolecithin
(Emulsifying, Surfactant)
9
Retinyl Linoleate
(Skin Conditioning)
1
Hydroxyphenyl Propamidobenzoic Acid
(Skin Conditioning)
1
B
Cetyl Palmitate
(Fragrance, Emollient, Masking, Skin Conditioning)
3
B
Laureth-23
(Cleansing, Emulsifying, Surfactant)
Bad for Oily Skin
Bad for Oily Skin
1
Sodium Hyaluronate Crosspolymer
(Humectant, Skin Conditioning)
3
Tocopheryl Acetate
(Antioxidant, Skin Conditioning)
Bad for Oily Skin
Bad for Oily Skin
1
A
Glyceryl Caprylate
(Skin Conditioning, Emollient, Emulsifying, Surfactant)
1
p-Anisic Acid
(Flavoring Agent, Fragrance, Masking)
Glycine Soja Oil
(Perfuming, Skin Conditioning, Skin Conditioning Emollient)
3
B
Sodium Hydroxide
(Denaturant, Ph Adjuster, Buffering Agent)
1
A
Sodium Hyaluronate
(Skin Conditioning, Humectant)
Good for Dry Skin
Good for Dry Skin
2
Thioctic Acid
(Antioxidant)
Trideceth-6 Phosphate
(Emulsifying, Surfactant)
1
Sodium Acetylated Hyaluronate
(Humectant)
1
Ubiquinone
(Antioxidant, Skin Conditioning)
TOCOPHEROL
(Antioxidant, Fragrance, Skin Conditioning)
2
A
Citric Acid
(Chelating Agent, Fragrance, Ph Adjuster, Buffering Agent, Masking)
Bad for Sensitive Skin
Bad for Sensitive Skin
1
A
Hyaluronic Acid
(Skin Conditioning, Viscosity Increasing Agent, Antistatic Agent, Humectant, Moisturising)
1
Hydrolyzed Glycosaminoglycans
(Hair Conditioning, Skin Conditioning, Humectant)
Hydrolyzed Sodium Hyaluronate
(Skin Conditioning)
1
A
1,2-Hexanediol
(Solvent)
4
B
Lactic Acid
(Exfoliant, Fragrance, Humectant, Ph Adjuster, Skin Conditioning Agent Humectant, Skin Conditioning, Buffering Agent)
Bad for Sensitive Skin
Bad for Sensitive Skin
3
A
Sodium Benzoate
(Fragrance, Preservative, Anticorrosive, Masking)
1
A
Ascorbyl Palmitate
(Antioxidant, Masking)
Fungal Acne
Fungal Acne Trigger
3
A
Potassium Sorbate
(Fragrance, Preservative)
1
Hydrolyzed Hyaluronic Acid
(Hair Conditioning, Humectant, Skin Conditioning)
2
Beta-Carotene
(Skin Conditioning)
Good for Dry Skin
Good for Dry Skin
daucus carota sativa root extract
(Skin Conditioning)
1
Phytic Acid
(Chelating Agent, Oral Care Agent)
1
Caprylhydroxamic Acid
(Chelating Agent)
1
A
Beta-Sitosterol
(Emulsion Stabilising, Masking, Skin Conditioning, Stabilising)
1
A
Squalene
(Hair Conditioning, Skin Conditioning, Emollient, Antistatic Agent, Refatting)
Fungal Acne
Fungal Acne Trigger
1
Arginine/Lysine Polypeptide
(Skin Conditioning)

My Ingredient Notes

No personal ingredient notes yet. Save ingredients to your profile to get good/bad alerts here.

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Key ingredients

Glycerin
Humectant, Skin Protecting
Dimethicone
Skin Protecting, Emollient
Squalane
Emollient, Skin Conditioning
Butylene Glycol
Skin Conditioning, Humectant
Niacinamide
Skin Conditioning
Lactobacillus Ferment
Skin Conditioning

Benefits

Good for dry skin
Good for oily/acne-prone skin

Concerns

Contains paraben
Contains silicone
Not fungal acne (malassezia) safe
Retinol — higher EWG
Retinyl Linoleate — higher EWG
May not suit sensitive skin

EWG flags hazard, not real-world risk — ratings don't account for how much of an ingredient a product contains. Treat these as things to research, not verdicts. How we score →

Ingredients explained

Water
Solvent
Low-hazard ingredient.Read moreShow less
EWG 1 Solvent
Propanediol
Solvent, Viscosity decreasing agent
Low-hazard ingredient.Read moreShow less
EWG 1 SolventViscosity decreasing agentViscosity controlling
Squalane
Emollient, Hair conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A EmollientHair conditioningRefattingSkin conditioning
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Emulsion stabilising, Viscosity controlling
Low-hazard ingredient.Read moreShow less
EWG 1 Emulsion stabilisingViscosity controlling
Niacinamide
Hair conditioning, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Hair conditioningSkin conditioningSmoothing
Rubus Idaeus Seed Oil
Skin conditioning emollient
Limited public safety data.Read moreShow less
EWG N/A Skin conditioning emollient
Lactobacillus Ferment
Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 Skin conditioning
Polyacrylate Crosspolymer-6
Emulsion stabilising, Viscosity controlling
Low-hazard ingredient.Read moreShow less
EWG 1 Emulsion stabilisingViscosity controlling
Pentylene Glycol
Skin conditioning, Solvent
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Skin conditioningSolvent
Caprylic/Capric Triglyceride
Emollient, Masking
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A EmollientMaskingPerfumingSkin conditioningSolvent
Ethylhexylglycerin
Deodorant, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A DeodorantSkin conditioning
Linum Usitatissimum Seed Extract
Perfuming, Skin conditioning
Limited public safety data.Read moreShow less
EWG N/A PerfumingSkin conditioning
Tetrasodium Glutamate Diacetate
Chelating agent
Low-hazard ingredient.Read moreShow less
EWG 1 Chelating agent
Mannose
Humectant
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Humectant
Sodium Mannose Phosphate
Humectant, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 HumectantSkin conditioning
+ 31 more — see the full ingredients list above
Glycerin
Denaturant, Fragrance
Low-hazard ingredient.Read moreShow less
EWG 2 CIR A DenaturantFragranceHair conditioningHumectantOral care agentOral health care drugSkin protectingViscosity decreasing agentPerfumingSolvent Good for Dry SkinFungal-acne trigger
Dimethicone
Antifoaming agent, Skin protecting
Low-to-moderate hazard.Read moreShow less
EWG 3 CIR A Antifoaming agentSkin protectingEmollientSkin conditioning Silicone
Butylene Glycol
Fragrance, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A FragranceSkin conditioningSolventViscositydecreasing agentHumectantMaskingViscosity controlling Good for Dry Skin
Phenoxyethanol
Fragrance, Preservative
Low-to-moderate hazard.Read moreShow less
EWG 4 CIR A FragrancePreservative Paraben
Allantoin
Skin conditioning, Skin protecting
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Skin conditioningSkin protectingSoothing Good for Oily SkinGood for Sensitive Skin
Aloe Barbadensis Leaf
Masking
Limited public safety data.Read moreShow less
EWG N/A CIR B Masking Good for Sensitive Skin
Retinol
Skin conditioning
Potentially a skin irritantRead moreShow less
EWG 9 CIR A Skin conditioning Bad for Sensitive Skin
Polysorbate 20
Emulsifying, Surfactant
Low-to-moderate hazard.Read moreShow less
EWG 3 CIR B EmulsifyingSurfactant Fungal-acne trigger
Polysorbate 60
Emulsifying, Surfactant
Low-to-moderate hazard.Read moreShow less
EWG 3 CIR B EmulsifyingSurfactant Fungal-acne trigger
Retinyl Linoleate
Skin conditioning
Higher-hazard ingredient.Read moreShow less
EWG 9 Skin conditioning
Laureth-23
Cleansing, Emulsifying
Potentially comedogenic - can block poresRead moreShow less
EWG 3 CIR B CleansingEmulsifyingSurfactant Bad for Oily Skin
Tocopheryl Acetate
Antioxidant, Skin conditioning
Potentially comedogenic - can block poresRead moreShow less
EWG 3 AntioxidantSkin conditioning Bad for Oily Skin
Sodium Hyaluronate
Skin conditioning, Humectant
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Skin conditioningHumectant Good for Dry Skin
Citric Acid
Chelating agent, Fragrance
Skin irritation can occur at high concentrationRead moreShow less
EWG 2 CIR A Chelating agentFragrancePh adjusterBuffering agentMasking Bad for Sensitive Skin
Lactic Acid
Exfoliant, Fragrance
Skin irritation can occur at high concentrationRead moreShow less
EWG 4 CIR B ExfoliantFragranceHumectantPh adjusterSkin-conditioning agent -humectantSkin conditioningBuffering agent Bad for Sensitive Skin
+ 3 more — see the full ingredients list above

How to use

How to use

  • 1 Where it fits: Apply after toner and before moisturiser — thinnest to thickest.
  • 2 Evening: Use at night — start 2–3× a week and build up as your skin tolerates it.
  • 3 Wear SPF the next day: Acids and retinoids increase sun sensitivity — daily sunscreen is a must while using this.

General guidance from this product's category and active ingredients — always follow the directions on the package.

Trust & honesty

Pregnancy & breastfeeding

Contains ingredients some choose to avoid or double-check while pregnant or nursing.

Often avoided
Retinoids (Vitamin A) (Retinol, Retinyl Linoleate)

Topical retinoids (retinol, retinaldehyde, retinyl esters) are widely advised against in pregnancy as a precaution. The strongest evidence is for ORAL retinoids; topical absorption is low, but most clinicians err on the side of caution.

This is general information, not medical advice. Pregnancy guidance varies and depends on concentration and your individual situation — always check with your doctor, midwife or pharmacist. How we flag this.

Effective levels — general guide

The concentrations these actives are typically effective at in research — not a measurement of this product.

Retinoids (Vitamin A) 0.01–1%

Most studied between 0.1% and 1%. Higher is not automatically better — irritation climbs with dose, so a well-formulated lower strength is often the sweet spot.

Retinol, Retinyl Linoleate

Vitamin C (ascorbic) 5–20%

L-ascorbic acid is usually used at 5–20% (around 10–15% is common). Above ~20% adds little and tends to irritate more; it also needs a low pH to work.

Ascorbyl Palmitate

Niacinamide 2–5% (up to 10%)

Most research uses 2–5%; some formulas go to 10%. Very high levels can cause flushing in sensitive skin.

Niacinamide

AHA (acid exfoliant) 5–10% (OTC)

OTC leave-on AHAs are usually 5–10%. The effect also depends on pH and free-acid value, not the percentage alone.

Lactic Acid

INCI lists don't disclose amounts, and we don't claim to know this product's levels — these are the ranges these ingredients are usually effective at, so you can tell a real formula from "fairy-dusting" a marketed active. How we estimate this.

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