Medicinal Wrinkle Serum White

SANA

Where to buy Possibly in stock

About this product

The SANA Medicinal Wrinkle Serum White is a serums, essence, ampoule. Our analysis of its 22 ingredients (14 low-risk) rates it Excellent (91/100). Based on its ingredients, it looks well-suited to oily / acne-prone skin.

Reef-safe

Summarised from our ingredient analysis — not brand marketing copy.

At a glance

Type
Serums, Essence, Ampoules
Ingredients
22
Low-risk
14
Fragrance
Fragrance-free
Origin
Japan

The evidence

Quick Product Notes

Paraben-Free Sulfate-Free Alcohol-Free Silicone-Free EU Allergen-Free Fungal Acne (Malassezia) Safe

Notable Effects & Ingredients

No Notable Effects & Ingredients

Ingredients Related to Skin Types

Good   Bad — tap a skin type to see which ingredients · estimated from ingredient functions
Dry Skin 4/5
Good for dry skin
Isostearyl Isostearate Butylene Glycol Glycerin Lactic Acid
Caution for dry skin
Cyclodextrin Glycerin Alcohol Hydrogenated Lecithin PEG-40 Hydrogenated Castor Oil
Oily/Acne-Prone Skin 2/0
Good for oily/acne-prone skin
Alcohol Retinol
Sensitive Skin 1/9
Good for sensitive skin
Glycerin
Caution for sensitive skin
Cellulose Gum Arginine Butylene Glycol Glycerin Alcohol PEG-40 Hydrogenated Castor Oil Lactic Acid Phenoxyethanol Retinol

Ingredients list

22 total
Lower hazard (1) Higher hazard (9)
All22 Skin Conditioning18 Fragrance7 Emulsion Stabilising4 Viscosity Controlling4 Solvent4 Masking4 Humectant4 Perfuming3
EWG CIR Ingredient Name & Cosmetic Functions Notes
1
A
Niacinamide
(Hair Conditioning, Skin Conditioning, Smoothing)
1
Water
(Solvent)
2
A
Glycerin
(Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care Agent, Oral Health Care Drug, Skin Protecting, Viscosity Decreasing Agent, Perfuming, Solvent)
Good for Dry Skin
Good for Dry Skin
Fungal Acne
Fungal Acne Trigger
1
A
Butylene Glycol
(Fragrance, Skin Conditioning, Solvent, Viscositydecreasing Agent, Humectant, Masking, Viscosity Controlling)
Good for Dry Skin
Good for Dry Skin
2
Alcohol
(Antifoaming Agent, Antimicrobial, Astringent, Masking, Solvent, Viscosity Controlling)
Bad for Dry Skin
Bad for Dry Skin
Bad for Sensitive Skin
Bad for Sensitive Skin
Ethyl Ethylhexanoate
(Perfuming)
Milk Ferment
(Skin Conditioning)
9
A
Retinol
(Skin Conditioning)
Bad for Sensitive Skin
Bad for Sensitive Skin
4
B
Lactic Acid
(Exfoliant, Fragrance, Humectant, Ph Adjuster, Skin Conditioning Agent Humectant, Skin Conditioning, Buffering Agent)
Bad for Sensitive Skin
Bad for Sensitive Skin
N-Stearoyl-Dihydrosphingosine
(Skin Conditioning)
1
A
Cyclodextrin
(Absorbent, Chelating Agent)
1
A
Arginine
(Fragrance, Hair Conditioning, Skin Conditioning, Antistatic Agent, Masking)
1
A
Carbomer
(Emulsion Stabilising, Viscosity Increasing Agent, Gel Forming, Viscosity Controlling)
1
A
Cellulose Gum
(Binding Agent, Emulsion Stabilising, Film Forming, Fragrance, Viscosity Increasing Agent, Binding, Masking, Viscosity Controlling)
A
Biosaccharide Gum-4
(Skin Conditioning)
Glycine Soja Extract
(Skin Conditioning)
1
B
Isostearyl Isostearate
(Binding Agent, Skin Conditioning, Emollient, Binding)
Bad for Oily Skin
Bad for Oily Skin
Fungal Acne
Fungal Acne Trigger
1
A
Phytosterols
(Skin Conditioning)
3
B
PEG-40 Hydrogenated Castor Oil
(Fragrance, Emulsifying, Surfactant, Perfuming)
Fungal Acne
Fungal Acne Trigger
3
B
Potassium Hydroxide
(Ph Adjuster, Buffering Agent)
2
A
Hydrogenated Lecithin
(Skin Conditioning, Emulsifying, Surfactant, Suspending Agent Nonsurfactant)
4
A
Phenoxyethanol
(Fragrance, Preservative)
Paraben
Paraben

My Ingredient Notes

No personal ingredient notes yet. Save ingredients to your profile to get good/bad alerts here.

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Key ingredients

Niacinamide
Skin Conditioning
Glycerin
Humectant, Skin Protecting
Butylene Glycol
Skin Conditioning, Humectant
Alcohol
Astringent
Milk Ferment
Skin Conditioning
Retinol
Skin Conditioning

Benefits

Good for oily/acne-prone skin

Concerns

Contains paraben
Not fungal acne (malassezia) safe
Retinol — higher EWG
May not suit dry skin
May not suit sensitive skin

EWG flags hazard, not real-world risk — ratings don't account for how much of an ingredient a product contains. Treat these as things to research, not verdicts. How we score →

Ingredients explained

Niacinamide
Hair conditioning, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Hair conditioningSkin conditioningSmoothing
Water
Solvent
Low-hazard ingredient.Read moreShow less
EWG 1 Solvent
Ethyl Ethylhexanoate
Perfuming
Limited public safety data.Read moreShow less
EWG N/A Perfuming
Milk Ferment
Skin conditioning
Limited public safety data.Read moreShow less
EWG N/A Skin conditioning
N-Stearoyl-Dihydrosphingosine
Skin conditioning
Limited public safety data.Read moreShow less
EWG N/A Skin conditioning
Cyclodextrin
Absorbent, Chelating agent
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A AbsorbentChelating agent
Arginine
Fragrance, Hair conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A FragranceHair conditioningSkin conditioningAntistatic agentMasking
Carbomer
Emulsion stabilising, Viscosity increasing agent
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Emulsion stabilisingViscosity increasing agentGel formingViscosity controlling
Cellulose Gum
Binding agent, Emulsion stabilising
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Binding agentEmulsion stabilisingFilm formingFragranceViscosity increasing agentBindingMaskingViscosity controlling
Biosaccharide Gum-4
Skin conditioning
Limited public safety data.Read moreShow less
EWG N/A CIR A Skin conditioning
Glycine Soja Extract
Skin conditioning
Limited public safety data.Read moreShow less
EWG N/A Skin conditioning
Phytosterols
Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Skin conditioning
Potassium Hydroxide
Ph adjuster, Buffering agent
Low-to-moderate hazard.Read moreShow less
EWG 3 CIR B Ph adjusterBuffering agent
Hydrogenated Lecithin
Skin conditioning, Emulsifying
Low-hazard ingredient.Read moreShow less
EWG 2 CIR A Skin conditioningEmulsifyingSurfactantSuspending agent- nonsurfactant
Glycerin
Denaturant, Fragrance
Low-hazard ingredient.Read moreShow less
EWG 2 CIR A DenaturantFragranceHair conditioningHumectantOral care agentOral health care drugSkin protectingViscosity decreasing agentPerfumingSolvent Good for Dry SkinFungal-acne trigger
Butylene Glycol
Fragrance, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A FragranceSkin conditioningSolventViscositydecreasing agentHumectantMaskingViscosity controlling Good for Dry Skin
Alcohol
Antifoaming agent, Antimicrobial
Causes moisture evaporation - prone to dry out skinRead moreShow less
EWG 2 Antifoaming agentAntimicrobialAstringentMaskingSolventViscosity controlling Bad for Dry SkinBad for Sensitive Skin
Retinol
Skin conditioning
Potentially a skin irritantRead moreShow less
EWG 9 CIR A Skin conditioning Bad for Sensitive Skin
Lactic Acid
Exfoliant, Fragrance
Skin irritation can occur at high concentrationRead moreShow less
EWG 4 CIR B ExfoliantFragranceHumectantPh adjusterSkin-conditioning agent -humectantSkin conditioningBuffering agent Bad for Sensitive Skin
Isostearyl Isostearate
Binding agent, Skin conditioning
Potentially comedogenic - can block poresRead moreShow less
EWG 1 CIR B Binding agentSkin conditioningEmollientBinding Bad for Oily SkinFungal-acne trigger
PEG-40 Hydrogenated Castor Oil
Fragrance, Emulsifying
Low-to-moderate hazard.Read moreShow less
EWG 3 CIR B FragranceEmulsifyingSurfactantPerfuming Fungal-acne trigger
Phenoxyethanol
Fragrance, Preservative
Low-to-moderate hazard.Read moreShow less
EWG 4 CIR A FragrancePreservative Paraben

How to use

How to use

  • 1 Where it fits: Apply after toner and before moisturiser — thinnest to thickest.
  • 2 Evening: Use at night — start 2–3× a week and build up as your skin tolerates it.
  • 3 Wear SPF the next day: Acids and retinoids increase sun sensitivity — daily sunscreen is a must while using this.

General guidance from this product's category and active ingredients — always follow the directions on the package.

Trust & honesty

Pregnancy & breastfeeding

Contains ingredients some choose to avoid or double-check while pregnant or nursing.

Often avoided
Retinoids (Vitamin A) (Retinol)

Topical retinoids (retinol, retinaldehyde, retinyl esters) are widely advised against in pregnancy as a precaution. The strongest evidence is for ORAL retinoids; topical absorption is low, but most clinicians err on the side of caution.

This is general information, not medical advice. Pregnancy guidance varies and depends on concentration and your individual situation — always check with your doctor, midwife or pharmacist. How we flag this.

Effective levels — general guide

The concentrations these actives are typically effective at in research — not a measurement of this product.

Retinoids (Vitamin A) 0.01–1%

Most studied between 0.1% and 1%. Higher is not automatically better — irritation climbs with dose, so a well-formulated lower strength is often the sweet spot.

Retinol

Niacinamide 2–5% (up to 10%)

Most research uses 2–5%; some formulas go to 10%. Very high levels can cause flushing in sensitive skin.

Niacinamide

AHA (acid exfoliant) 5–10% (OTC)

OTC leave-on AHAs are usually 5–10%. The effect also depends on pH and free-acid value, not the percentage alone.

Lactic Acid

INCI lists don't disclose amounts, and we don't claim to know this product's levels — these are the ranges these ingredients are usually effective at, so you can tell a real formula from "fairy-dusting" a marketed active. How we estimate this.

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