Advanced Defense Serum

Cetaphil

Where to buy Possibly in stock

About this product

The Cetaphil Advanced Defense Serum is a serums, essence, ampoule. Our analysis of its 16 ingredients (14 low-risk) rates it Excellent (100/100). Based on its ingredients, it looks well-suited to dry and sensitive skin.

Vegan-friendly Reef-safe

Summarised from our ingredient analysis — not brand marketing copy.

At a glance

Type
Serums, Essence, Ampoules
Ingredients
16
Low-risk
14
Fragrance
Fragrance-free
Origin
United States
Data updated
May 2026

The evidence

Quick Product Notes

Paraben-Free Sulfate-Free Alcohol-Free Silicone-Free EU Allergen-Free Fungal Acne (Malassezia) Safe

Notable Effects & Ingredients

No Notable Effects & Ingredients

Ingredients Related to Skin Types

Good   Bad — tap a skin type to see which ingredients · estimated from ingredient functions
Dry Skin 5/1
Good for dry skin
Butylene Glycol Sodium Hyaluronate Polyglyceryl-4 Caprate Hydrolyzed Hyaluronic Acid PEG/PPG-8/3 Laurate
Caution for dry skin
Polyglyceryl-4 Caprate
Oily/Acne-Prone Skin No data
Sensitive Skin 3/2
Good for sensitive skin
Tocopheryl Acetate Allantoin Epigallocatechin Gallatyl Glucoside
Caution for sensitive skin
Butylene Glycol Citric Acid

Ingredients list

16 total
Lower hazard (1) Higher hazard (3)
All16 Skin Conditioning16 Solvent4 Humectant4 Antioxidant3 Hair Conditioning3 Fragrance3 Masking2 Viscosity Controlling2
EWG CIR Ingredient Name & Cosmetic Functions Notes
1
Water
(Solvent)
1
A
Butylene Glycol
(Fragrance, Skin Conditioning, Solvent, Viscositydecreasing Agent, Humectant, Masking, Viscosity Controlling)
Good for Dry Skin
Good for Dry Skin
3
PEG/PPG-8/3 Laurate
(Emulsifying, Emulsion Stabilising, Hair Conditioning, Humectant)
1
A
Pentylene Glycol
(Skin Conditioning, Solvent)
1
B
Polyglyceryl-4 Caprate
(Skin Conditioning, Emollient, Emulsifying, Surfactant)
1
A
1,2-Hexanediol
(Solvent)
1
A
Niacinamide
(Hair Conditioning, Skin Conditioning, Smoothing)
Epigallocatechin Gallatyl Glucoside
(Antioxidant, Skin Conditioning)
1
Hydrolyzed Hyaluronic Acid
(Hair Conditioning, Humectant, Skin Conditioning)
1
A
Allantoin
(Skin Conditioning, Skin Protecting, Soothing)
Good for Oily Skin
Good for Oily Skin
Good for Sensitive Skin
Good for Sensitive Skin
3
Tocopheryl Acetate
(Antioxidant, Skin Conditioning)
Bad for Oily Skin
Bad for Oily Skin
1
Ammonium Acryloyldimethyltaurate/VP Copolymer
(Viscosity Controlling)
1
A
Sodium Hyaluronate
(Skin Conditioning, Humectant)
Good for Dry Skin
Good for Dry Skin
TOCOPHEROL
(Antioxidant, Fragrance, Skin Conditioning)
1
A
Sodium Gluconate
(Chelating Agent, Skin Conditioning)
2
A
Citric Acid
(Chelating Agent, Fragrance, Ph Adjuster, Buffering Agent, Masking)
Bad for Sensitive Skin
Bad for Sensitive Skin

My Ingredient Notes

No personal ingredient notes yet. Save ingredients to your profile to get good/bad alerts here.

Browse similar serums, essence, ampoule
No close formula match yet — browse other products like this

Key ingredients

Antioxidants
Shields skin from free radical damage.
Vitamin E
Protects skin and soothes irritation.
Hyaluronic Acid
Hydrates by attracting and holding water.
Niacinamide
Strengthens, smooths, and brightens skin.

Benefits

HydratingBoosts hydration and relieves dry, tight skin.
Barrier RepairStrengthen and restore your skin's natural barrier.
Redness ReducingSoothes visible redness and calms irritation.
Anti-AgingSoftens lines and helps skin look youthful.
BrighteningRestores radiance to dull, tired skin.
Reduces IrritationEases discomfort and supports skin resilience.
Scar HealingImproves the look of marks and scars.
Dark SpotsFades dark spots for even skin tone.

Concerns

No major concerns flagged

Ingredients explained

Water
Solvent
Low-hazard ingredient.Read moreShow less
EWG 1 Solvent
PEG/PPG-8/3 Laurate
Emulsifying, Emulsion stabilising
Low-to-moderate hazard.Read moreShow less
EWG 3 EmulsifyingEmulsion stabilisingHair conditioningHumectant
Pentylene Glycol
Skin conditioning, Solvent
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Skin conditioningSolvent
Polyglyceryl-4 Caprate
Skin conditioning, Emollient
Low-hazard ingredient.Read moreShow less
EWG 1 CIR B Skin conditioningEmollientEmulsifyingSurfactant
1,2-Hexanediol
Solvent
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Solvent
Niacinamide
Hair conditioning, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Hair conditioningSkin conditioningSmoothing
Epigallocatechin Gallatyl Glucoside
Antioxidant, Skin conditioning
Limited public safety data.Read moreShow less
EWG N/A AntioxidantSkin conditioning
Hydrolyzed Hyaluronic Acid
Hair conditioning, Humectant
Low-hazard ingredient.Read moreShow less
EWG 1 Hair conditioningHumectantSkin conditioning
Ammonium Acryloyldimethyltaurate/VP Copolymer
Viscosity controlling
Low-hazard ingredient.Read moreShow less
EWG 1 Viscosity controlling
TOCOPHEROL
Antioxidant, Fragrance
Limited public safety data.Read moreShow less
EWG N/A AntioxidantFragranceSkin conditioning
Sodium Gluconate
Chelating agent, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Chelating agentSkin conditioning
Butylene Glycol
Fragrance, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A FragranceSkin conditioningSolventViscositydecreasing agentHumectantMaskingViscosity controlling Good for Dry Skin
Allantoin
Skin conditioning, Skin protecting
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Skin conditioningSkin protectingSoothing Good for Oily SkinGood for Sensitive Skin
Tocopheryl Acetate
Antioxidant, Skin conditioning
Potentially comedogenic - can block poresRead moreShow less
EWG 3 AntioxidantSkin conditioning Bad for Oily Skin
Sodium Hyaluronate
Skin conditioning, Humectant
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Skin conditioningHumectant Good for Dry Skin
Citric Acid
Chelating agent, Fragrance
Skin irritation can occur at high concentrationRead moreShow less
EWG 2 CIR A Chelating agentFragrancePh adjusterBuffering agentMasking Bad for Sensitive Skin

How to use

How to use

  • 1 Where it fits: Apply after toner and before moisturiser — thinnest to thickest.
  • 2 Morning & evening: Suitable for both AM and PM use.

General guidance from this product's category and active ingredients — always follow the directions on the package.

Trust & honesty

Effective levels — general guide

The concentrations these actives are typically effective at in research — not a measurement of this product.

Niacinamide 2–5% (up to 10%)

Most research uses 2–5%; some formulas go to 10%. Very high levels can cause flushing in sensitive skin.

Niacinamide

INCI lists don't disclose amounts, and we don't claim to know this product's levels — these are the ranges these ingredients are usually effective at, so you can tell a real formula from "fairy-dusting" a marketed active. How we estimate this.

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