Deep Hydration 48 Hour Activation Serum

Cetaphil

Deep Hydration 48 Hour Activation Serum

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About this product

The Cetaphil Deep Hydration 48 Hour Activation Serum is a serums, essence, ampoule. Our analysis of its 29 ingredients (24 low-risk) rates it Excellent (98/100). Based on its ingredients, it looks well-suited to dry skin.

Vegan-friendly Reef-safe

Summarised from our ingredient analysis — not brand marketing copy.

At a glance

Type
Serums, Essence, Ampoules
Ingredients
29
Low-risk
24
Fragrance
Fragrance-free
Origin
United States
Data updated
Jun 2026

The evidence

Quick Product Notes

Paraben-Free Sulfate-Free Alcohol-Free Silicone-Free EU Allergen-Free Fungal Acne (Malassezia) Safe

Notable Effects & Ingredients

No Notable Effects & Ingredients

Ingredients Related to Skin Types

Good   Bad — tap a skin type to see which ingredients · estimated from ingredient functions
Dry Skin 15/5
Good for dry skin
Glyceryl Citrate/Lactate/Linoleate/Oleate Dicaprylyl Carbonate Anhydroxylitol Sorbitol Octyldodecanol Xylitol Xylitylglucoside Glycerin Propylene Glycol Coco-Caprylate/Caprate Pantolactone Hydrolyzed Hyaluronic Acid Hexyldecyl Laurate Hexyldecanol Sodium Polyacrylate
Caution for dry skin
Disodium Cocoyl Glutamate Distarch Phosphate Glycerin Sodium Polyacrylate Sodium Hydroxide
Oily/Acne-Prone Skin No data
Sensitive Skin 2/7
Good for sensitive skin
Glycerin Tocopheryl Acetate
Caution for sensitive skin
Sorbitol Octyldodecanol Glycerin Propylene Glycol Citric Acid Sodium Benzoate Phenoxyethanol

Ingredients list

29 total
Lower hazard (1) Higher hazard (4)
All29 Skin Conditioning22 Humectant13 Fragrance9 Emollient6 Solvent5 Hair Conditioning3 Emulsion Stabilising3 Film Forming3
EWG CIR Ingredient Name & Cosmetic Functions Notes
1
Water
(Solvent)
2
A
Glycerin
(Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care Agent, Oral Health Care Drug, Skin Protecting, Viscosity Decreasing Agent, Perfuming, Solvent)
Good for Dry Skin
Good for Dry Skin
Fungal Acne
Fungal Acne Trigger
1
Sorbitol
(Flavoring Agent, Fragrance, Humectant, Plasticizer, Skin Conditioning)
1
B
Coco-Caprylate/Caprate
(Emollient, Skin Conditioning)
1
A
Glyceryl Citrate/Lactate/Linoleate/Oleate
(Skin Conditioning, Emollient, Emulsifying)
Helianthus Annuus Seed Oil
(Fragrance, Skin Conditioning, Skin Conditioning Emollient)
1
A
Octyldodecanol
(Fragrance, Skin Conditioning, Emollient, Perfuming, Solvent)
1
Hexyldecanol
(Skin Conditioning, Emollient, Humectant, Solvent)
1
Hexyldecyl Laurate
(Emollient, Skin Conditioning)
1
Distarch Phosphate
(Anticaking Agent, Binding Agent, Absorbent, Binding)
1
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
(Emulsion Stabilising, Film Forming, Viscosity Controlling)
1
Anhydroxylitol
(Humectant, Skin Conditioning)
Butyrospermum Parkii Oil
(Skin Conditioning, Skin Conditioning Emollient)
2
A
Citric Acid
(Chelating Agent, Fragrance, Ph Adjuster, Buffering Agent, Masking)
Bad for Sensitive Skin
Bad for Sensitive Skin
1
Dicaprylyl Carbonate
(Skin Conditioning, Emollient)
1
B
Disodium Cocoyl Glutamate
(Cleansing, Surfactant)
Globularia Alypum Leaf Extract
(Skin Conditioning)
1
Hydrolyzed Hyaluronic Acid
(Hair Conditioning, Humectant, Skin Conditioning)
1
A
Panthenol
(Antistatic Agent, Hair Conditioning, Skin Conditioning)
Good for Dry Skin
Good for Dry Skin
1
Pantolactone
(Humectant)
4
A
Phenoxyethanol
(Fragrance, Preservative)
Paraben
Paraben
3
B
Propylene Glycol
(Fragrance, Humectant, Skin Conditioningagent Miscellaneous, Solvent, Viscosity Decreasing Agent, Skin Conditioning, Viscosity Controlling)
Good for Dry Skin
Good for Dry Skin
3
A
Sodium Benzoate
(Fragrance, Preservative, Anticorrosive, Masking)
3
B
Sodium Hydroxide
(Denaturant, Ph Adjuster, Buffering Agent)
3
B
Sodium Polyacrylate
(Absorbent, Emulsion Stabilising, Film Forming, Hair Fixing, Skin Conditioning Agent Emollient, Viscosity Controlling Agent, Viscosity Increasing Agent, Binding, Skin Conditioning)
TOCOPHEROL
(Antioxidant, Fragrance, Skin Conditioning)
3
Tocopheryl Acetate
(Antioxidant, Skin Conditioning)
Bad for Oily Skin
Bad for Oily Skin
1
Xylitol
(Flavoring Agent, Humectant, Skin Conditioning)
1
Xylitylglucoside
(Humectant, Skin Conditioning)

My Ingredient Notes

No personal ingredient notes yet. Save ingredients to your profile to get good/bad alerts here.

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Key ingredients

Vitamin E
Protects skin and soothes irritation.
Antioxidants
Shields skin from free radical damage.
Hyaluronic Acid
Hydrates by attracting and holding water.

Benefits

HydratingBoosts hydration and relieves dry, tight skin.
Barrier RepairStrengthen and restore your skin's natural barrier.
Scar HealingImproves the look of marks and scars.
Anti-AgingSoftens lines and helps skin look youthful.
BrighteningRestores radiance to dull, tired skin.
Redness ReducingSoothes visible redness and calms irritation.
Reduces IrritationEases discomfort and supports skin resilience.
Dark SpotsFades dark spots for even skin tone.

Concerns

Contains paraben
Not fungal acne (malassezia) safe
May not suit sensitive skin

Ingredients explained

Water
Solvent
Low-hazard ingredient.Read moreShow less
EWG 1 Solvent
Sorbitol
Flavoring agent, Fragrance
Low-hazard ingredient.Read moreShow less
EWG 1 Flavoring agentFragranceHumectantPlasticizerSkin conditioning
Coco-Caprylate/Caprate
Emollient, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR B EmollientSkin conditioning
Glyceryl Citrate/Lactate/Linoleate/Oleate
Skin conditioning, Emollient
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Skin conditioningEmollientEmulsifying
Helianthus Annuus Seed Oil
Fragrance, Skin conditioning
Limited public safety data.Read moreShow less
EWG N/A FragranceSkin conditioningSkin conditioning emollient
Octyldodecanol
Fragrance, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A FragranceSkin conditioningEmollientPerfumingSolvent
Hexyldecanol
Skin conditioning, Emollient
Low-hazard ingredient.Read moreShow less
EWG 1 Skin conditioningEmollientHumectantSolvent
Hexyldecyl Laurate
Emollient, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 EmollientSkin conditioning
Distarch Phosphate
Anticaking agent, Binding agent
Low-hazard ingredient.Read moreShow less
EWG 1 Anticaking agentBinding agentAbsorbentBinding
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Emulsion stabilising, Film forming
Low-hazard ingredient.Read moreShow less
EWG 1 Emulsion stabilisingFilm formingViscosity controlling
Anhydroxylitol
Humectant, Skin conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 HumectantSkin conditioning
Butyrospermum Parkii Oil
Skin conditioning, Skin conditioning emollient
Limited public safety data.Read moreShow less
EWG N/A Skin conditioningSkin conditioning emollient
Dicaprylyl Carbonate
Skin conditioning, Emollient
Low-hazard ingredient.Read moreShow less
EWG 1 Skin conditioningEmollient
Disodium Cocoyl Glutamate
Cleansing, Surfactant
Low-hazard ingredient.Read moreShow less
EWG 1 CIR B CleansingSurfactant
Globularia Alypum Leaf Extract
Skin conditioning
Limited public safety data.Read moreShow less
EWG N/A Skin conditioning
+ 8 more — see the full ingredients list above
Glycerin
Denaturant, Fragrance
Low-hazard ingredient.Read moreShow less
EWG 2 CIR A DenaturantFragranceHair conditioningHumectantOral care agentOral health care drugSkin protectingViscosity decreasing agentPerfumingSolvent Good for Dry SkinFungal-acne trigger
Citric Acid
Chelating agent, Fragrance
Skin irritation can occur at high concentrationRead moreShow less
EWG 2 CIR A Chelating agentFragrancePh adjusterBuffering agentMasking Bad for Sensitive Skin
Panthenol
Antistatic agent, Hair conditioning
Low-hazard ingredient.Read moreShow less
EWG 1 CIR A Antistatic agentHair conditioningSkin conditioning Good for Dry Skin
Phenoxyethanol
Fragrance, Preservative
Low-to-moderate hazard.Read moreShow less
EWG 4 CIR A FragrancePreservative Paraben
Propylene Glycol
Fragrance, Humectant
Low-to-moderate hazard.Read moreShow less
EWG 3 CIR B FragranceHumectantSkin-conditioningagent - miscellaneousSolventViscosity decreasing agentSkin conditioningViscosity controlling Good for Dry Skin
Tocopheryl Acetate
Antioxidant, Skin conditioning
Potentially comedogenic - can block poresRead moreShow less
EWG 3 AntioxidantSkin conditioning Bad for Oily Skin

How to use

How to use

  • 1 Where it fits: Apply after toner and before moisturiser — thinnest to thickest.
  • 2 Morning & evening: Suitable for both AM and PM use.

General guidance from this product's category and active ingredients — always follow the directions on the package.

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